Myelodysplastic syndrome in a 30-year-old man with coronavirus disease 2019 (COVID-19): a diagnostic challenge

Background: Myelodysplastic syndromes (MDS) mainly occur in the elderly but can rarely affect younger individuals too. The correct diagnosis relies on careful morphologic evaluation, cytogenetic/molecular results, and excluding reactive conditions mimicking MDS. We present the clinical, pathologic, cytogenetic, and molecular features of a case of MDS with excess blasts-2 (MDS-EB-2) in a 30-year-old male who was found to have pancytopenia during his hospitalization for coronavirus disease 2019 (COVID-19) and discuss the diagnostic challenges of MDS in patients with COVID-19. Case presentation: A 30-year-old man presented to an outside hospital with fever, chills, weakness, coughing spells, dizziness and shortness of breath and was diagnosed with bilateral pneumonia due to COVID-19. At the outside hospital, he was found to be pancytopenic, and a subsequent bone marrow aspiration and biopsy raised concern for a COVID-19 induced hemophagocytic lymphohistiocytosis. In addition, MDS could not be ruled out. The patient was thus referred to our institute for further management. The patient’s peripheral blood showed pancytopenia with occasional dysplastic neutrophils and a few teardrop cells. Given the diagnostic uncertainty, a bone marrow aspiration and a biopsy were repeated revealing a hypercellular bone marrow with erythroid hyperplasia, megakaryocytic hyperplasia, trilineage dysplasia, increased blasts (13%), many ring sideroblasts, and mild to moderate myelofibrosis, consistent with MDS-EB-2. Chromosomal analysis revealed isochromosome 14. Next generation sequencing demonstrated SF3B1 K700E mutation. Discussion and conclusion: The diagnosis of MDS can be challenging, particularly in young patients. Cytopenia and myelodysplastic features have been reported in COVID-19 patients, making the diagnosis of MDS more elusive. A careful pathologic examination of the bone marrow with ancillary studies including flow cytometry, immunohistochemistry, and cytogenetic and molecular studies in combination with a thorough clinical evaluation, leads to the accurate diagnosis

Place-based film for growing community engagement in local marine conservation

Awareness, knowledge and community identity can grow from local narratives about conservation and enhance our capacity for environmental stewardship. New media narrative approaches are also seeking to improve the terms of community engagement across a spectrum of stakeholders. For instance, film is increasingly being used by scientists and policymakers to situate science stories within a community in order to increase local ownership and enhance engagement, be it through active participation in conservation or to support/social license. Here, the use of placebased documentary film as a tool to affect these outcomes is explored in a community adjacent to a controversial marine reserve, and we focus in particular on the effect of film on local youth

LATIN AMERICA IN THE TWENTY-FIRST CENTURY: REASSESSING THE UNITED STATES – LATIN AMERICA RELATIONSHIP THROUGH EXAMINING REGIONAL STABILITY

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Dyadic influence of hope and optimism on patient marital satisfaction among couples with advanced breast cancer

PURPOSE: An estimated 10-40 % of breast cancer (BC) patients report negative changes to their partnered relationships. Literature suggests that for these patients, marital satisfaction is related to depression and other quality of life factors which are associated with survivorship and treatment response. However, existing literature does not provide a clear explanation of the factors that strengthen vs. create strain in couples facing cancer. Given the benefits of a satisfying relationship to patient quality of life, it is important to better understand factors that put patients at greater risk for marital difficulties. This study examined the differential and combined roles of hope and optimism among BC patients and their partners on patient marital satisfaction. METHOD: Fifty-six breast cancer patient-partner dyads completed study questionnaires as part of a larger study. Regression analyses were used to examine the main and interaction effects of patient and partner hope and optimism on patient marital satisfaction. RESULTS AND CONCLUSION: Higher patient and partner hope predicted greater patient marital satisfaction, whereas optimism did not. These results are divergent from the literature on optimism and well-being, which shows the importance of studying these two traits concurrently. Interaction effects suggest certain combinations of patient and partner hope and optimism are more beneficial than others for patient marital satisfaction and suggest a dyadic approach is important for investigation of well-being in breast cancer

Marketing and Engagement Like a Tiger

Lightning Round - SCLA Conference, November 9th, 201

When ‘Places’ Include Pets: Broadening the Scope of Relational Approaches to Promoting Aging-in-Place

Aging-in-place is a well-established concept, but discussions rarely consider that many older adults live with pets. In a ‘pet-friendly’ city, we conducted semi-structured interviews to explore perspectives of community-based social support agencies that promote aging-in-place, and those of animal welfare agencies. Applying a relational ecology theoretical framework, we found that pets may contribute to feeling socially- situated, yet may also exacerbate constraints on autonomy experienced by some older adults. Pet-related considerations at times led to discretionary acts of more-than-human solidarity, but also created paradoxical situations for service-providers, impacting their efforts to assist older adults. A shortage of pet-friendly affordable housing emerged as an overarching challenge. Coordination among social support and animal welfare agencies, alongside pet-supportive housing policies, will strengthen efforts to promote aging-in-place in ways that are equitable and inclusive

School Counselors and Administrators Agree: Time and Testing are Barriers

School leaders continuously state their concerns about rising mental health issues in schools. This study looks at the perceptions of the roles of school counselors as mental health professionals in schools from the perspectives of school counselors and principals. The purpose of this study is to explore how administrators and school counselors describe the role of school counselors, and the perceived barriers to school counselors spending the recommended 80 percent of their time in the delivery of services to students. This study uses deductive qualitative content analysis to review written responses from the 518 participants who identified as either a licensed or certified school counselor or a school administrator. The results show that school administrators and school counselors have very different perceptions of school counselors as mental health professionals; however, they agree that time and testing are barriers to providing direct services to students. RésuméLes dirigeants d’écoles expriment sans cesse leurs préoccupations envers l’augmentation des problèmes de santé mentale dans les écoles. Cette étude examine comment les directeurs et les conseillers en orientation perçoivent les rôles de ces derniers entant que professionnels de santé mentale dans les écoles. Le but de cette étude est d’explorer comment les administrateurs et les conseillers en orientation décrivent le rôle de ces derniers et les obstacles qui les empêcheraient de consacrer 80 pour cent de leur temps (tel que recommandé) à servir les élèves. Cette étude utilise une analyse de contenu qualitative et déductive pour examiner les réponses écrites des 518 participants qui se sont identifiés comme étant soit un conseiller en orientation certifié, soit un administrateur scolaire. Les résultats montrent que les administrateurs et les conseillers en orientation ont des perceptions très différentes de ces derniers en tant que professionnels de santé mentale; cependant, ils conviennent tous que le manque de temps et les tests posent un défi à la capacité des conseillers à servir les élèves directement. Keywords / Mots clés : school counselors, administrators, roles and responsibilities, barriers / conseillers en orientation, administrateurs, rôles et responsabilités, obstacle

Long-Lived In-Situ Solar System Explorer (LLISSE)

This presentation and poster provide a brief overview on the Long-Lived In-situ Solar System Explorer (LLISSE). This is a small probe being developed to provide long-term measurements of simple but important scientific parameters from the surface of Venus. This is a revolutionary concept to Venus exploration and promises to change our paradigm of exploring this unique and challenging environment

Long-Lived In-Situ Solar System Explorer (LLISSE)

This presentation provides an update on development of the Long-Lived In-situ Solar System Explorer (LLISSE). LLISSE is a small probe being developed to provide long-term measurements of simple but important scientific parameters from the surface of Venus. High level summary of recent activities and progress is provided. LLISSE is a small and completely independent probe for Venus surface application